总体简介

药物化学博士，前诺和诺德美国研究中心主任科学家，美国罗氏生物制药子公司马卡迪亚多肽和蛋白质化学研发主任总监。曾在美国印第安那大学化学系先后担任研究助理教授和副教授。研究背景覆盖药物化学，多肽和蛋白质药物化学，药物合成设计，分子生物学和生物化学领域。在新药研究的特殊贡献是最早参与研究新型多靶点多功能肠促胰素类多肽药物(GLP-1/Incretin)，并首次研究报道抗糖尿病和肥胖症新型药物GLP-1/GIP/GCG三靶点多功能肠促胰素多肽药物的药物化学家 (Nature Medicine, 2015)。

个人简历

· 08/1990 – 07/1996: 药物化学硕士博士，北京军事医学科学院药物所

? 07/2023 –至今 ：浙江工业大学莫干山研究院，浙江德清

? 02/2016– 5/2023: 诺和诺德美国印第安纳波利斯研发中心， 资深科学家/主任科学家

? 01/2012 - 01/2016：美国印第安纳大学化学系副研究员/研究副教授

? 08/2008 - 12/2011: 美国马卡迪亚 (罗氏)生物公司， 多肽化学研发主任

荣誉与学术兼职：

省级项目入选者

青岛科技大学客座教授

论文、项目与专利等成果

发表文章（5篇）

1. Brian Finan^#(共同第一作者, biology), Bin Yang^#(共同第一作者, chemistry), Nickki Ottaway, David L Smiley, Tao Ma, Christoffer Clemmensen, Joe Chabenne, Lianshan Zhang, Kirk M Habegger, Katrin Fischer, Jonathan E Campbell, Darleen Sandoval, Randy J Seeley, Konrad Bleicher, Sabine Uhles, William Riboulet, Jürgen Funk, Cornelia Hertel, Sara Belli, Elena Sebokova, Karin Conde-Knape, Anish Konkar, Daniel J Drucker, Vasily Gelfanov, Paul T Pfluger, Timo D Müller, Diego Perez-Tilve, Richard D DiMarchi & Matthias H Tsch?p. A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents. Nature Medicine, 2015，21：27–36 .  (GLP-1/GIP/GCG三靶点Incretins药物领域的首次发表文章)

2. Bin Yang, Vasily M. Gelfanov, Kimberley El, Alex Chen, Rebecca Rohlfs, Barent DuBois, Ann Maria Kruse Hansen, Diego Perez-Tilve, Patrick J. Knerr, David D'Alessio, Jonathan E. Campbell, Jonathan D. Douros, Brian Finan. Discovery of a potent GIPR peptide antagonist that is effective in rodent and human systems. Molecular Metabolism, 2022, Dec, Volume 66: 101638.

3. Bin Yang*, Vasily M. Gelfanov, Diego Perez-Tilve, Barent DuBois, Rebecca Rohlfs, Jay Levy, Jonathan D. Douros, Brian Finan, John P. Mayer, and Richard D. DiMarchi. Optimization of Glucagon Truncated Peptides to Achieve Selective, High Potency, Full Antagonists. Journal of Medicinal Chemistry, 2021, 64, 4697 – 4708.

4. Finan B, Bin Yang, Ottaway N, Kerstin Stemmer, Timo D Müller, …, Richard D DiMarchi & Matthias H Tsch?p. Targeted estrogen delivery reverses the metabolic syndrome.  Nature Medicine. 2012, 18(12): 1847-1856.

5. Hui Zhang*, Bin Yang, Roger J. Pomerantz, Chune Zhang, Shyamala C. Arunachalam, and Ling Gao. The Cytidine Deaminase CEM15 Induces Hypermutation in Newly Synthesized HIV-1 DNA. Nature, 2003, 424(6944): 94-98. (Hui Zhang was PI, Bin Yang was the main contributor).

项目和专利（5篇）

1. Richard DiMarchi and Bin Yang. Insulin Nuclear Hormone Conjugates. WO2017210242A1; PCT/US2017/035102

2. Richard DiMarchi and Bin Yang. Glucagon superfamily peptides exhibiting glucocorticoid receptor activity. US20130157934

3. Richard DiMarchi, David L. Smiley and Bin S. Yang. Glucagon/GLP-1 receptor co-agonists. US-2012329707-A1

4. Richard DiMarchi, Bin Yang and Brian Finan. Glucagon Superfamily Peptides Exhibiting Nuclear Hormone Receptor Activity. US 9127088, 20130123178

5. Richard DiMarchi, Bin Yang and Chenguang Ouyang. “Compounds Exhibiting Glucagon Antagonist and GLP-1 Agonist”.  US8980830, WO2009058734